PReS-FINAL-2086: In vitro investigation of the sustained therapeutic effect of etanercept loaded microspheres on human rheumatoid arthritis fibroblast-like synoviocytes
نویسندگان
چکیده
Objectives We aimed to develop a sustained release system for an anti-TNFa drug in treatment of chronic inflammatory arthritis. A novel form of intra-articularly injectable etanercept (ETN) loaded poly(ε-caprolactone) (PCL) or methoxy poly(ethylene glycol)-poly(ε-caprolactone)methoxy poly(ethylene glycol) (MPEG-PCL-MPEG) microspheres (patent pending) were prepared to provide long term controlled release of ETN with a sustained anti-inflammatory effect as a local treatment approach.
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